It is perpetually tempting to imagine letting the red states (whose voters imagine that they are getting the short end of the stick, when in fact they are vastly subsidized) go their own way. Tempting, but both impossible and harmful.
Much better, as cogently explained here by @interfluidity, is to build things up in the red states, so that their citizens perceive that they have an economic and political stake in the United States.
“The only way to mitigate this tendency towards corrosive crisis is to ensure that differences of interest between larger and smaller states are generally modest.”