Tag: longevity

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Overview of my results from Superpower.com

If you’ve been following me for any length of time, you know I’m big on metrics. It’s why I own both an Oura Ring and a Pixel watch. I am similarly interested in the annual blood work I get from my doctor’s office. That last though is often not quite as much or as often as I want, so I was very interested when Superpower reached out to offer me an extensive panel of blood work, if I’d post a review of their service.

This offer came at a particularly opportune time, as I’d been thinking of trying to get at least one specific test run ahead of my next physical. (I’d gotten a result that was slightly out-of-range on my creatinine test. This is common if you’re taking creatine, which I had been, but I still wanted to verify that it wasn’t indicative of a kidney problem. So, I’d gone off creatine, and wanted to re-run the test and be sure that my values had returned to normal.)

Getting a physical scheduled these days takes a ridiculous lead time, so it was going to be months before I got that blood work done. As I said, this made me want some other path to getting that test.

Enter Superpower, which is a way to get a vast suite of blood work done, but it’s much more than that. They have an AI trained on all these tests, with access to your results, that can integrate them together and answer questions about them. The answers are probably very similar to what your doctor could provide, except your doctor isn’t likely to have a couple of hours to go through your results line-by-line, the way I did last night with the Superpower AI.

You could get a reasonable read on any one of these markers just by googling the test name, but the Superpower AI has all your other results at its fingertips as well, so it can relate one value to another. For example, one of the blood tests measured my cortisol levels, and Superpower had this to say:

“Your cortisol level of 11.1 mcg/dL sits comfortably in the optimal physiologic range (10–18 mcg/dL), which suggests your adrenal function and stress response are well balanced.”

That’s roughly what you could get just by doing a google search on cortisol test and looking at the reference range. (Superpower is slightly better, because you won’t have to slog through the high values, the low values, the normal values, or the difference between the reference range and the optimal value.) But Superpower can do even better, because it has all your other data. For example, for me it goes on to say

  • This level indicates your hypothalamic–pituitary–adrenal (HPA) axis is functioning normally—not underactive (as in adrenal fatigue or insufficiency) and not overproducing cortisol (as with chronic stress, inflammation, or metabolic strain).
  • Given your low hs‑CRP (0.9 mg/L), balanced glucose (A1c 5.4%), and strong energy habits, your body is managing everyday physiological stressors efficiently.
  • You also show good DHEA‑S (88 mcg/dL), suggesting adrenal reserve is intact and age‑appropriate. The cortisol‑to‑DHEA‑S ratio is within the healthy range, a good sign of adaptive—not excessive—stress output.

I knew nothing about DHEA‑S, so reading what the Superpower AI said about it was instructive.

There were dozens of other tests (I think 160 in the basic panel), so the part of my brain that wants all the metrics was very happy indeed. If you’re like me, and just want the metrics, Superpower seems great: Lots of metrics and a very useful AI tool to tell you what they mean.

If you’re not like me, and you’re just interested in improving your health and performance, the value of Superpower isn’t quite as clear, but I think there is some value:

  • Every result that’s in the “optimal” range is one more thing to not worry about, and that’s useful.
  • Every value that’s in the “good” range (normal but not optimal) is a thing you could work on to improve your health or performance, and the AI will make some suggestions for how you could work to optimize all your blood work.
  • Every value that’s out of the reference range is, maybe, something you ought to talk to your doctor about.

That last is a bit uncertain. The doctors I’ve talked to over the years are pretty down on the idea of taking every test and then worrying about every value that’s out of the reference range. There are a few values (blood sugar, LDL cholesterol), where it’s both a clear sign that there’s something wrong that’s likely to lead to specific harms and there are practical treatments available that can reduce those harms. But just because a number is out of range isn’t much of a reason to do anything, unless there’s some symptom that’s plausibly related.

You almost certainly know what you ought to be doing to optimize your health. Eat food. Move a lot. Sleep well. (If not, read my post I’ve spent too much time thinking about longevity, which gives you a very slightly longer version of that same overview.)

Given that you know those things already, what would paying Superpower to run a bunch of blood tests do for your health and performance? That is: who is Superpower for?

First of all, it’s for people like me: People who just like having a bunch of metrics.

Second, it’s for people like me: People with a specific question to ask, like my question about creatinine levels.

Third, it’s for people who have trouble getting their doctor to go through all their test results with them. Of course any doctor who won’t go over any out-of-range results with you needs to be replaced. But ordinary blood work won’t even mention which of your results are in the reference range but outside the optimal range, and even a good doctor isn’t going to have time to go through those results and help you figure out how to improve them. The Superpower AI is a great tool for going through the normal-but-not-optimal results and coming up with a plan for optimizing your health.

Fourth, it’s for people who like the reassurance of being able to say, “Okay, I’ve got that one covered,” when one of the metrics is optimal, while being able to say, “Ah, but this other one could use a little more effort,” when one of the metrics is a little off. And, of course, there’s always the possibility that it’ll clue you in to something serious that you ought to take to your doctor.

So, how did I use it? Well, my creatinine levels had come back normal, so I’ve restarted creatine. My blood lipids are still a little off, even though I started a drug for that, so I have another thing to talk to my doctor about. Other than that, pretty much everything is normal, and most values are optimal, so I’m in that comfortable zone of feeling like I don’t have much to worry about.

How about the future? I just got the basic suite of blood work, and there are several options if I want to pay more money, and some of them are attractive.

For example, I’d be very interested to know about my magnesium levels. (Magnesium is very important in many cellular processes.) It’s not impossible to get enough magnesium from your diet—lots of foods have some magnesium in them—but there’s no one or two foods where you can just say, “Eat a couple of servings of this or that,” and you can be confident that you’ve got that base covered.

As another example, there are several B vitamins that need to be methylated to be turned into their active form, and people have a diversity of enzymes to do that, some of which are better than others. There are genetic tests to see if you have the gene for one of the good enzymes or one of the bad ones, but there are also tests to see if the vitamins in your blood are properly methylated, offered in the Methylation Specialty Panel. That’s another one that appeals to me.

I’ll consider those. If I decide to spring for them, I’ll follow up here in the future.

In the meantime, I’m pretty pleased with what I got: Something just for me.

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I’ve been thinking about longevity too long and too hard. It isn’t something that I suddenly started doing when I reached my 60s, or even when I hit middle age. I can remember as a high school student figuring out that I’d need to live about two thousand years to have time to learn and do all the stuff I wanted to learn and do.

Sadly, everything we know now suggests that lifestyle improvements can get you a life extension of 7 years—maybe as much as 11 years, if you get serious about it. I mean, that’s not nothing, but it’s not going to get me to two thousand years, or even to eleventy-one, like Bilbo. (That’s what I lowered my sights to, when I realized that two thousand years was unlikely.)

“Immortal Holding a Peach” at the Metropolitan Museum of Art. In the public domain.

I was briefly pretty hopeful in the late 1980s, when it looked like nanotech might produce amazing longevity gains. But, no. Turns out except for a few materials-science things—stuff like that tweaking the surface of glass to make it self-cleaning—the only nanotech that anyone has been able to get to do anything remotely interesting is biotech. I mean, MRNA vaccines are awesome, but nothing like the nanotech we were promised.

Considering how much is written about longevity, the stuff that actually works offers pretty minimal benefits. Getting a life extension of 7 to 11 years look pretty easy, just by doing the obvious, boring stuff, and practically none of the fancy bio-hacky things have any evidence behind them at all.

So what are the boring things that work?

Eat food

Don’t eat industrially produced food-like substances. Eat in reasonable amounts. Eat diversely. I saw one study that suggested that any exclusion-based diet—keto, carnivore, vegan, etc.—seemed to be associated with poorer health outcomes. (On the other hand, if one of those things produces benefits in the short term—for me, it’s eating low-carb—there’s no reason not to do it long enough to reap those benefits. But long-term you want a diverse diet.)

Exercise

Until recently the only real evidence-based exercise advice was for 150 minutes per week of moderate-intensity exercise (brisk walking, basically). But recently it has become very clear that maintaining muscle mass, strength, and power are beneficial in multiple ways (everything from reducing falls to providing a glucose sink). Separately, a high V̇O2 max is strongly associated with a longer life. So although there’s little evidence for weight lifting, running, or high-intensity cardo, there is now very good evidence that the entirely expectable results of those exercise modalities are excellent for longevity. So: diverse exercise is going to help you live longer.

Manage your blood pressure, blood glucose, and blood lipids

Really good diet and exercise can maybe eliminate the need for drugs. But taking the drugs if you need them can help a lot.

Enjoy life

There’s good evidence of benefit from social connection. There’s good evidence of benefit from time spent in nature. There’s good evidence of benefit from having a positive mental attitude. (All those are suspect, because being sick makes them tougher to do, so you’re selecting out some fraction of the people who are going to die young, which makes the statistics misleading. But there’s not much point in a long life unless you’re going to enjoy it, so why not?)

Other stuff

I’ve refrained from mentioning the bio-hacky stuff that I’ve spent way too much time thinking about. Not just the nanotech stuff, but also all the rest: All of the supplements, sleep hacks, drinking more (or less) coffee (or tea or bone broth or mushroom-enhanced beverages), etc.

It’s not that things like sleep aren’t important. It’s that there’s essentially no evidence that any specific intervention is going to help in a measurable way. In fact, there can’t ever be any such evidence. The experiment can’t be done. And if it were done, the effect wouldn’t be measurable.

I mean, if you have a diagnosis for a problem—sleep apnea, for example—then treating that problem could very easily be transformational, not just for your longevity, but for your life right now. But giving everyone a CPAP machine would do no good. Furthermore, picking a few random sleep hacks—avoiding caffeine after mid-day, wearing blue-blocker glasses, or tweaking your pre-bedtime routine—isn’t going to make any difference across the population. (Any one of those might help you in particular, and if it does, more power to you. But none of those, even if adopted by 100% of the population, is going to add a year to the average lifespan.)

If you’re interested in details, you might look at the recent New York Times article “The Key to Longevity Is Boring.” Another option would be to read the Peter Attia book Outlive, or listen to his most recent podcast episode, Longevity 101, either of which does a great job of covering the handful of things that will give you that extra 7 to 11 years of life.

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You don’t have to know much about me to know that the latest video from The Bioneer on training for longevity is like catnip for me:

You will not be surprised to learn that the advice comes down to move more, move more diversely, and learn a lot. (Of course, adding diverse complex movements is learning.) But there is also specific useful advice re: power, bone density, tendon strength, etc.